I have PCOS and have tried clomiphene. It helped me get pregnant, though it ended in early miscarriage. I only ovulated once i used it with metformin though. The real downside is the side effects. I had hot flashes (like felt like I was on fire from the inside) and had dramatic emotional shifts. I felt like I was bipolar the way it would change so fast. But it can work, so that is good. About to try another round since our break after miscarriage.